Monday, January 10, 2011

Pigment Density and Naturalized Serum Vitamin D

Regarding vitamin D supplementation and melatonin and how it may relate to the spot on the back of your hand…

Doctor Cannell writes this;

The Vitamin D Newsletter August 2006

If you are scientific, try a little experiment. Take someone you know with fair skin who burns easily and who doesn't go in the sun. Take him or her into a sun tan booth and find out exactly how many minutes it takes for their skin to just begin to turn pink, called one minimal erythemal dose (MED). Then, keep them out of the sun but give them 10,000 units of vitamin D a day for a month. Then take them into the sun tan booth again and see how long it takes for them to get one MED. What you will discover is that their time for one MED is longer. High vitamin D blood levels help prevent burning and facilitate tanning.

The only thing that would lengthen a MED should be more active melatonin.

Freckles/Sun spots

When you are born there can be an excess of melanocytes in a particular area and as you age and become exposed to the sun, these begin to produce areas of pigmentation. Over time, and as a result of prolonged exposure to the sun and insufficient sun protection, these areas may darken and become more numerous.

So it would appear normalized serum vitamin D stimulates melanocytes. But what is the trigger that the sun induces in the skin biology to trigger the melanocytes.

And the data proves me out…

Do not worry about your hand but go and research pigment deposits, vitamin D, tyrosinase and melanocytes.
Stimulation of human melanocytes by vitamin D3 possibly mediates skin pigmentation after sun exposure
Y Tomita, W Torinuki… - Journal of Investigative Dermatology, 1988 - nature.com
... Stimulation of Human Melanocytes by Vitamin D 3 Possibly Mediates Skin Pigmentation After

 Abstract. We found an increased amount of immunoreactive tyrosinase in human melanocytes after 6-d culturing with vitamin D 3 (cholecalciferol). ...

Cited by 35 - Related articles - All 4 versions

We found an increased amount of immunoreactive tyrosinase in human melanocytes after 6-d culturing with vitamin D3 (cholecalciferol). Most of these melanocytes became more dendritic and swollen in a fashion similar to that noted in the skin after ultraviolet irradiation. However, 7-dehydrocholesterol (pro-vitamin D3) or 1,25-dihydroxy-vitamin D3 (activated vitamin D3) were found to have little effect on the same system. Because vitamin D3 is known to be photochemically converted from pro-vitamin D3 in the skin by Ultraviolet irradiation, the mechanism of human skin pigmentation after ultraviolet irradiation, thus far unknown, may be at least partly explained by this stimulating effect of vitamin D3 on melanocytes.


In all likelyhood what you are seeing is a concentrated area of melanocytes responding to normalized serum vitamin D.

Regardless of what the dermatologist says when you see him the spot is far more likely to be an activated, concentrated area of pigment deposit. As a freckled red head you have lots of those, and one of them is more dense than most of the others.

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